If you develop applications with HTML select fields you know that anything longer than 10 options is a recipie for customer complaints, and usability nightmares, well the guys of Harvest (http://www.getharvest.com) provide Chosen a way to make select fields more useable, searcheable with even a Facebook like select for multiple options. This is also used in their timesheet and invoicing software.
1. You need to pick a framework for which you have support within your organization, area that you live or industry vertical that you are working in. I call this stage picking your poison
This my take on the topic started at http://tinyurl.com/3fhw7hb from personal experience.
MySQL (http:/www.mysql.com), the web database formely fully open source, then bought by Sun for $1bn, which was then swallowed by the all mighty database giant Oracle (http://www.oracle.com) is finally growing up.